Impact of natural resources and research on cancer treatment and prevention: A perspective from Cameroon
Identifieur interne : 000222 ( Main/Exploration ); précédent : 000221; suivant : 000223Impact of natural resources and research on cancer treatment and prevention: A perspective from Cameroon
Auteurs : Barnabas Bessem Orang-Ojong ; Jose Edward Munyangaju ; Ma Shang Wei ; Miao Lin ; Fan Guan Wei ; Charles Foukunang [Cameroun] ; Yan ZhuSource :
- Molecular and Clinical Oncology [ 2049-9450 ] ; 2013.
Abstract
Cancer is a significant public health concern and treatment poses a problem and is frequently unsuccessful. As such, continuous efforts in the search for new agents and therapies to improve survival are required. A considerable number of plant extracts and isolated compounds possess significant anti-proliferative or pro-apoptotic effects. The majority of biologically active compounds belong to terpenoids, phenolics and alkaloids. Terpenoid plants such as
Url:
DOI: 10.3892/mco.2013.132
PubMed: 24649217
PubMed Central: 3916164
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Impact of natural resources and research on cancer treatment and prevention: A perspective from Cameroon</title><author><name sortKey="Orang Ojong, Barnabas Bessem" sort="Orang Ojong, Barnabas Bessem" uniqKey="Orang Ojong B" first="Barnabas Bessem" last="Orang-Ojong">Barnabas Bessem Orang-Ojong</name><affiliation><nlm:aff id="af1-mco-01-04-0610">Tianjin State Key Laboratory of Modern Chinese Medicine, Institute of Traditional Chinese Medicine and Development, Tianjin University of Traditional Chinese Medicine, Tianjin 300139,<country>P.R. China</country>;</nlm:aff><wicri:noCountry code="nlm country">P.R. China</wicri:noCountry></affiliation></author><author><name sortKey="Munyangaju, Jose Edward" sort="Munyangaju, Jose Edward" uniqKey="Munyangaju J" first="Jose Edward" last="Munyangaju">Jose Edward Munyangaju</name><affiliation><nlm:aff id="af1-mco-01-04-0610">Tianjin State Key Laboratory of Modern Chinese Medicine, Institute of Traditional Chinese Medicine and Development, Tianjin University of Traditional Chinese Medicine, Tianjin 300139,<country>P.R. China</country>;</nlm:aff><wicri:noCountry code="nlm country">P.R. China</wicri:noCountry></affiliation></author><author><name sortKey="Wei, Ma Shang" sort="Wei, Ma Shang" uniqKey="Wei M" first="Ma Shang" last="Wei">Ma Shang Wei</name><affiliation><nlm:aff id="af1-mco-01-04-0610">Tianjin State Key Laboratory of Modern Chinese Medicine, Institute of Traditional Chinese Medicine and Development, Tianjin University of Traditional Chinese Medicine, Tianjin 300139,<country>P.R. China</country>;</nlm:aff><wicri:noCountry code="nlm country">P.R. China</wicri:noCountry></affiliation></author><author><name sortKey="Lin, Miao" sort="Lin, Miao" uniqKey="Lin M" first="Miao" last="Lin">Miao Lin</name><affiliation><nlm:aff id="af1-mco-01-04-0610">Tianjin State Key Laboratory of Modern Chinese Medicine, Institute of Traditional Chinese Medicine and Development, Tianjin University of Traditional Chinese Medicine, Tianjin 300139,<country>P.R. China</country>;</nlm:aff><wicri:noCountry code="nlm country">P.R. China</wicri:noCountry></affiliation></author><author><name sortKey="Wei, Fan Guan" sort="Wei, Fan Guan" uniqKey="Wei F" first="Fan Guan" last="Wei">Fan Guan Wei</name><affiliation><nlm:aff id="af1-mco-01-04-0610">Tianjin State Key Laboratory of Modern Chinese Medicine, Institute of Traditional Chinese Medicine and Development, Tianjin University of Traditional Chinese Medicine, Tianjin 300139,<country>P.R. China</country>;</nlm:aff><wicri:noCountry code="nlm country">P.R. China</wicri:noCountry></affiliation></author><author><name sortKey="Foukunang, Charles" sort="Foukunang, Charles" uniqKey="Foukunang C" first="Charles" last="Foukunang">Charles Foukunang</name><affiliation wicri:level="1"><nlm:aff id="af2-mco-01-04-0610">Department of Pharmacy and Traditional Pharmacopoeia Development, University of Yaoundé 1, Yaoundé and Faculty of Medicine University of Bamenda, Yaoundé 00237,<country>Cameroon</country></nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhu, Yan" sort="Zhu, Yan" uniqKey="Zhu Y" first="Yan" last="Zhu">Yan Zhu</name><affiliation><nlm:aff id="af1-mco-01-04-0610">Tianjin State Key Laboratory of Modern Chinese Medicine, Institute of Traditional Chinese Medicine and Development, Tianjin University of Traditional Chinese Medicine, Tianjin 300139,<country>P.R. China</country>;</nlm:aff><wicri:noCountry code="nlm country">P.R. China</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24649217</idno><idno type="pmc">3916164</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916164</idno><idno type="RBID">PMC:3916164</idno><idno type="doi">10.3892/mco.2013.132</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000513</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000513</idno><idno type="wicri:Area/Pmc/Curation">000512</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000512</idno><idno type="wicri:Area/Pmc/Checkpoint">000190</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000190</idno><idno type="wicri:Area/Ncbi/Merge">000304</idno><idno type="wicri:Area/Ncbi/Curation">000304</idno><idno type="wicri:Area/Ncbi/Checkpoint">000304</idno><idno type="wicri:doubleKey">2049-9450:2013:Orang Ojong B:impact:of:natural</idno><idno type="wicri:Area/Main/Merge">000223</idno><idno type="wicri:Area/Main/Curation">000222</idno><idno type="wicri:Area/Main/Exploration">000222</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Impact of natural resources and research on cancer treatment and prevention: A perspective from Cameroon</title><author><name sortKey="Orang Ojong, Barnabas Bessem" sort="Orang Ojong, Barnabas Bessem" uniqKey="Orang Ojong B" first="Barnabas Bessem" last="Orang-Ojong">Barnabas Bessem Orang-Ojong</name><affiliation><nlm:aff id="af1-mco-01-04-0610">Tianjin State Key Laboratory of Modern Chinese Medicine, Institute of Traditional Chinese Medicine and Development, Tianjin University of Traditional Chinese Medicine, Tianjin 300139,<country>P.R. China</country>;</nlm:aff><wicri:noCountry code="nlm country">P.R. China</wicri:noCountry></affiliation></author><author><name sortKey="Munyangaju, Jose Edward" sort="Munyangaju, Jose Edward" uniqKey="Munyangaju J" first="Jose Edward" last="Munyangaju">Jose Edward Munyangaju</name><affiliation><nlm:aff id="af1-mco-01-04-0610">Tianjin State Key Laboratory of Modern Chinese Medicine, Institute of Traditional Chinese Medicine and Development, Tianjin University of Traditional Chinese Medicine, Tianjin 300139,<country>P.R. China</country>;</nlm:aff><wicri:noCountry code="nlm country">P.R. China</wicri:noCountry></affiliation></author><author><name sortKey="Wei, Ma Shang" sort="Wei, Ma Shang" uniqKey="Wei M" first="Ma Shang" last="Wei">Ma Shang Wei</name><affiliation><nlm:aff id="af1-mco-01-04-0610">Tianjin State Key Laboratory of Modern Chinese Medicine, Institute of Traditional Chinese Medicine and Development, Tianjin University of Traditional Chinese Medicine, Tianjin 300139,<country>P.R. China</country>;</nlm:aff><wicri:noCountry code="nlm country">P.R. China</wicri:noCountry></affiliation></author><author><name sortKey="Lin, Miao" sort="Lin, Miao" uniqKey="Lin M" first="Miao" last="Lin">Miao Lin</name><affiliation><nlm:aff id="af1-mco-01-04-0610">Tianjin State Key Laboratory of Modern Chinese Medicine, Institute of Traditional Chinese Medicine and Development, Tianjin University of Traditional Chinese Medicine, Tianjin 300139,<country>P.R. China</country>;</nlm:aff><wicri:noCountry code="nlm country">P.R. China</wicri:noCountry></affiliation></author><author><name sortKey="Wei, Fan Guan" sort="Wei, Fan Guan" uniqKey="Wei F" first="Fan Guan" last="Wei">Fan Guan Wei</name><affiliation><nlm:aff id="af1-mco-01-04-0610">Tianjin State Key Laboratory of Modern Chinese Medicine, Institute of Traditional Chinese Medicine and Development, Tianjin University of Traditional Chinese Medicine, Tianjin 300139,<country>P.R. China</country>;</nlm:aff><wicri:noCountry code="nlm country">P.R. China</wicri:noCountry></affiliation></author><author><name sortKey="Foukunang, Charles" sort="Foukunang, Charles" uniqKey="Foukunang C" first="Charles" last="Foukunang">Charles Foukunang</name><affiliation wicri:level="1"><nlm:aff id="af2-mco-01-04-0610">Department of Pharmacy and Traditional Pharmacopoeia Development, University of Yaoundé 1, Yaoundé and Faculty of Medicine University of Bamenda, Yaoundé 00237,<country>Cameroon</country></nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhu, Yan" sort="Zhu, Yan" uniqKey="Zhu Y" first="Yan" last="Zhu">Yan Zhu</name><affiliation><nlm:aff id="af1-mco-01-04-0610">Tianjin State Key Laboratory of Modern Chinese Medicine, Institute of Traditional Chinese Medicine and Development, Tianjin University of Traditional Chinese Medicine, Tianjin 300139,<country>P.R. China</country>;</nlm:aff><wicri:noCountry code="nlm country">P.R. China</wicri:noCountry></affiliation></author></analytic><series><title level="j">Molecular and Clinical Oncology</title><idno type="ISSN">2049-9450</idno><idno type="eISSN">2049-9469</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Cancer is a significant public health concern and treatment poses a problem and is frequently unsuccessful. As such, continuous efforts in the search for new agents and therapies to improve survival are required. A considerable number of plant extracts and isolated compounds possess significant anti-proliferative or pro-apoptotic effects. The majority of biologically active compounds belong to terpenoids, phenolics and alkaloids. Terpenoid plants such as <italic>Hypericum lanceolatum</italic> and a few alkaloid plants have been found to be potent anti-parasitic agents but have exhibited poor antimicrobial effects. The screening of medicinal plants for anticancer drugs has provided modern medicine with effective cytotoxic pharmaceuticals. Numerous medicinal plants have traditionally been used for the treatment of various ailments. However, a number of these medicinal plants have not been standardized and their mechanisms of actions are generally unknown. Active drug discovery research using local medicinal plants is ongoing. Some of these plant-derived compounds, including 3,39-dimethoxy-49-<italic>O</italic>-β-<sc>d</sc>-xylopyronosylellagic acid, have been tested for their potential use as anticancer agents. 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Doh</name></author><author><name sortKey="Petignat, P" uniqKey="Petignat P">P Petignat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Angwafo, Ff" uniqKey="Angwafo F">FF Angwafo</name></author><author><name sortKey="Zaher, A" uniqKey="Zaher A">A Zaher</name></author><author><name sortKey="Befidi Mengue, R" uniqKey="Befidi Mengue R">R Befidi-Mengue</name></author><author><name sortKey="Wonkam, A" uniqKey="Wonkam A">A Wonkam</name></author><author><name sortKey="Takougang, I" uniqKey="Takougang I">I Takougang</name></author><author><name sortKey="Powell, I" uniqKey="Powell I">I Powell</name></author><author><name sortKey="Murphy, G" uniqKey="Murphy G">G Murphy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sow, M" uniqKey="Sow M">M Sow</name></author><author><name sortKey="Nkegoum, B" uniqKey="Nkegoum B">B Nkégoum</name></author><author><name sortKey="Oyono, Jl" uniqKey="Oyono J">JL Oyono</name></author><author><name sortKey="Garoua" uniqKey="Garoua">Garoua</name></author><author><name sortKey="Nzokou, A" uniqKey="Nzokou A">A Nzokou</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Cameroun</li></country></list><tree><noCountry><name sortKey="Lin, Miao" sort="Lin, Miao" uniqKey="Lin M" first="Miao" last="Lin">Miao Lin</name><name sortKey="Munyangaju, Jose Edward" sort="Munyangaju, Jose Edward" uniqKey="Munyangaju J" first="Jose Edward" last="Munyangaju">Jose Edward Munyangaju</name><name sortKey="Orang Ojong, Barnabas Bessem" sort="Orang Ojong, Barnabas Bessem" uniqKey="Orang Ojong B" first="Barnabas Bessem" last="Orang-Ojong">Barnabas Bessem Orang-Ojong</name><name sortKey="Wei, Fan Guan" sort="Wei, Fan Guan" uniqKey="Wei F" first="Fan Guan" last="Wei">Fan Guan Wei</name><name sortKey="Wei, Ma Shang" sort="Wei, Ma Shang" uniqKey="Wei M" first="Ma Shang" last="Wei">Ma Shang Wei</name><name sortKey="Zhu, Yan" sort="Zhu, Yan" uniqKey="Zhu Y" first="Yan" last="Zhu">Yan Zhu</name></noCountry><country name="Cameroun"><noRegion><name sortKey="Foukunang, Charles" sort="Foukunang, Charles" uniqKey="Foukunang C" first="Charles" last="Foukunang">Charles Foukunang</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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